Rink Amide Linker

Rink Amide Linker - Omizzur
* For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Rink Amide Linker



Molecular FormulaC32H29NO7
Pack size

Price ( USD )

25g$140.0In stock
100gMake inquiryIn stock
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General Description

Rink Amide Linker | Omizzur Biotech

1.Prospects of Peptides

Nature contains peptide compounds that play a crucial role in human growth, diseases, aging, and death. They are bioactive substances involved in various cellular functions within the organism.

Chemists made peptides using artificial methods. Peptide research has made amazing progress due to advances in molecular biology and biochemical technology. In recent years, people have widely recognized alternative medicine, natural drugs, and natural therapies.

2. Principles of Solid-phase Peptide Synthesis

Solid-phase synthesis connects the hydroxyl group of the last amino acid in a peptide chain to a polymer resin. This covalent bond structure attaches to a solid-phase carrier. The amino acid loses its amino protection group and combines with excess activated hydroxyl to make the peptide chain longer.

Repeat the process of condensation, washing, deprotection, neutralization, and washing to achieve the desired peptide chain length. Finally, we cleave the peptide chain from the resin and purify it to obtain the desired peptide. learn more about peptide synthesis click: custom peptide synthesis

Which method detects the completion of peptide synthesis by connecting each amino acid during the synthesis process?

One way is to use the ninhydrin color reaction to find out. This connection closes the N-terminal, stopping it from staining with ninhydrin. To improve accuracy, the best way is to use quantitative detection. During the connection process, we can detect the degree of resin substitution.

3. Important parameters of resins: crosslinking degree, mesh size, degree of substitution, swelling degree.

1. The crosslinking degree refers to the extent of crosslinking in a material, the purpose is to create resin balls.

The more divinylbenzene added, the higher the crosslinking degree (DVB), and the best resin crosslinking degree is 1%. More crosslinking = less swelling, but less crosslinking = less stability when swollen.

Generally speaking, most resins sold have a crosslinking degree of 1%.

2. Resin ball size: Typically, commercially available resins have a mesh size of 100-200 (with an average diameter of 75-150 μm).

The degree of substitution is the amount of active reaction sites per gram of resin, measured in mmol/g. After Wang resin and CTC resin become available, we will load the first amino acid in the lab. However, these resins cannot achieve a 100% amino acid loading rate. Therefore, the degree of substitution should be re determined after this.

3. Swelling ability: The swelling ability of a resin in different solvents, expressed in ml/g. After the general market resin is available, we need to use solvent for swelling before use. Good swelling can increase the chances of reactants entering the site. Commonly used benign resin swelling solvents include DCM, DMF, and N-methylpyrrolidone.

4. Rink Amide Linker

Rink amide resin is the most commonly used resin for preparing peptide amides, with a functional group of amino groups. Usually, we use Rink amine resin with amino groups protected by Fmoc. Remove Fmoc first when loading the first amino acid, and then proceed to the normal coupling washing deprotection cycle.

The linker in Rink amine resin is stable. However, it requires a significant amount of TFA cracking. This cracking process can lead to side reactions similar to those observed with Wang resin. If the peptide chain contains Trp residues, we should also pay attention to similar side effects.

Rink Aminde Linker Synthesis

Rink Amide Linker

4 Resins Characteristics Summary


Cracking Conditions

Cracking Products




High concentration TFA

Peptide acid

Cheap price, stable linker, high yield

Many side effects


Low concentration TFA

Peptide acid

Cheap price, it can avoid many side reactions of wang resin, can be used for fragment synthesis method

Very sensitive to water, the linker is unstable, which can affect the yield

Rink amind Linker

High concentration TFA

Peptide amide

Cheap price, stable linker, high yield

Irregular cracking of linker produces many side reactions


Low concentration TFA

Peptide amide

Used for fragment synthesis 

High price

Product Data Sheet

Rink Amide Linker Data


Fmoc-Rink Amide Linker

More synonym

4-[(2,4-Dimethoxyphenyl)(Fmoc-Amino)Methyl]Phenoxyacetic Acid



Molecular Formula


Molecular Weight



1.3±0.1 g/cm3

Boiling Point

776.3±60.0 °C at 760 mmHg

Melting Point


Flash Point

423.3±32.9 °C

Vapour Pressure

0.0±2.8 mmHg at 25°C

Storage condition


Shipping & Storage

Shipping by FedEx / DHL / by air, fast shipping worldwide.

Storage: 2-8°C 

Ordering Guide:

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