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Omizzur FAQs | Amino Acid Derivatives and Peptide Synthesis

01. What are amino acid derivatives?

Amino acids are the basic units of protein and peptides, but it is often inconvenient to use untreated amino acids directly in peptide synthesis in the laboratory. The reason is that there may be amino groups, carboxyl groups and different types of side chain functional groups in an amino acid molecule, and these groups may all participate in chemical reactions.

If not controlled, the reaction that was originally expected to happen in one place may happen at the same time in other places. Therefore, researchers often need to make certain chemical modifications to amino acids to form various amino acid derivatives.

Simply put, this process can be understood as "putting on a protective cap" for the part of the amino acid that temporarily does not want to participate in the reaction, and then removing the protective group after the target reaction is over.

02. Synthesis from a single amino acid to a complex peptide

A seemingly simple protected amino acid actually connects the whole peptide synthesis process. From the selection of protective groups, solid resin matching, to the stereochemical control and final analysis and verification, each step will affect the subsequent results.

Solid phase peptide synthesis (SPPS) is one of the commonly used methods in the preparation of peptides in laboratory. In this method, the first amino acid is usually connected to the solid resin, and then the cycle of "deprotection-coupling-deprotection-re-coupling" is completed according to the established order.

Common solid carriers include Wang Resin, Merrifield Resin and functionalized resins suitable for different protection strategies and product requirements. The combination of different resins and different amino acid derivatives will affect the assembly mode of peptide chains and the release conditions of the final products.

03. Application of Unnatural Amino Acids

The application of unnatural amino acids mainly focuses on drug development, protein engineering and biomaterials.

Peptide and protein drugs: Inserting unnatural amino acids into polypeptide or protein can obviously improve the membrane permeability, protease hydrolysis resistance and conformational rigidity of drugs, and also improve stability, half-life and biological activity.

Antibody-coupled drugs: Traditional ADC is randomly coupled by Cys or Lys on antibodies, and the products are uneven. Using unnatural amino acids to achieve fixed-point coupling can make ADC with high uniformity of DAR, improve curative effect and reduce toxicity.

04. How to Dissolve and Store Peptides?

Dissolving the peptide is a very important step. The peptide's ability to dissolve depends on its sequence, so be care when about that. We recommend including 20% of the charged residues in the peptide sequence. Our team can help you evaluate it. 

Dissolving peptides is usually a little test first, and do not dissolve all of them without determining a suitable solvent. Determining the charge of the peptide can help you choose the right solvent. Freeze-dried powder peptides can stably transport at room temp.

>> Learn more about peptide dissolution

05. How To Choose The Purity Levels of Peptide?

The purity of custom peptide synthesis is important and depends on the experiment's purpose. For less sensitive tests, use the crude product or >75%. For immune level tests, use >85%. 

When studying how receptors interact with ligands, we recommend using a purity of over 95%. We recommend a purity of 98% for structural studies. 98% highest quality for structural studies.

Crude peptides may contain amounts of non-peptide impurities. If TFA interferes with your test, we recommend other salt forms such as acetate, HCL type. You can ask our customer services for advice on the purity of peptides. You will receive a response within 1 hour.

06. How To Check The Quality of Peptides?

Omizzur provides HPLC and MS test results free of charge when sending products. COA,MS,HPLC,NMR,IR,analysis data are available. MS test results can also show most of the main impurities of peptide. All delivered peptides are of the purity required by the customer.

If you have any questions about product quality, please contact our customer services, and our team will do our best to help you.

07. What are the R&D Directions for Synthetic Peptides?

1.CPPs

CPPs are composed of usually no more than 30 amino acids that can directly enter the cell. They can successfully carry active things such as small molecule drugs, siRNAs into cells. We synthesize peptides very fast and high quality for R&D purpose.

2.Modified peptide - New form of peptide  

At present, most peptide products are injection form. improving the delivery method is the new R&D direction. 

Omizzur Amino acid Derivatives & Peptide Synthesis Service

Exenatide  Impurities, Quantity: 200mg Purity: 95.30%   Salmon Calcitonin Impurities Quantity: 200mg Purity: 95.16%    Fmoc-Lys(Boc)-OH Quantity: 50kg Purity: 99.91%

Liraglutide API CAS: 204656-20-2 Purity: 95.68%                 Semaglutide Peptide CAS: 910463-68-2  Purity: 99.50%                Fmoc-OSu CAS : 82911-69-1 Purity: 99.96%

Custom Peptide Synthesis | Amino Acid Derivatives Buy Online

  Quote Request / Order Peptides:

  [email protected] or click the button "Get a Quote From " below.

  * Please mail us your product sequences, CAS (if any), our customer services will get in touch with you within 1 hour.

• Omizzur biotech custom peptide synthesis price list here

  80-100mg: crude $11.5;>75% $29.0;>80% $30.8;>85% $33.0; >90% ,delivery time:2-3 weeks,HPLC/MS/COA report. We need to confirm the exact peptide sequences ,modification site of the product you need. please contact us for accurate quotation.

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  If you believe that our product does not meet your requirements, please contact us as soon as possible. Our customer services will assist you in get 100% qualified products. mail us for details.

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