Fmoc-Arg(Pbf)-OH | CAS:154445-77-9 | 99% Purity Spot Supply

Protected amino acids are the most basic raw materials for solid-phase peptide synthesis . Amino acids all contain alpha amino and carboxyl groups, and some of the 20 amino acids also contain side-chain active groups, such as hydroxyl, amino, guanidino and heterocyclic groups. These active groups need to be protected during the peptide reaction, and the protective groups are removed after the target peptide is synthesized.The most frequently used protected amino acid raw material is the Fmoc amino acids

Optimization of Fmoc Protected Amino acids Synthesis

In peptide synthesis, in order to obtain the ideal target peptide, it is first necessary to block or protect the active groups of amino acids. Boc and Fmoc are the preferred protective groups in solid-phase synthesis, forming two major categories of peptide solid-phase synthesis methods: boc and Fmoc method.

In the synthesis of Fmoc-Arg(Pbf)-OH, due to some unique advantages of the protective group of Fmoc, such as its instability towards bases and ease of detection, we chose Fmoc as its protective group. In the process of fmoc strategy synthesis, triphenylmethyl (trt) is stable for condensation and deprotection conditions. It can be removed by dilute acetic acid at slightly higher temperature conditions or TFA at room temperature. Therefore, Trt is chosen to block its active functional group. The experiment optimized the two-step protection reaction conditions of His using the central surface experimental design method and orthogonal experimental design method, resulting in a final yield of over 80% for both reactions and a product purity of over 96%.

Fmoc-Arg(Pbf)-OH (CAS:154445-77-9) Fmoc arginine is a kind of Fmoc protected amino acid, which can be selected from reagent grade and industrial grade. The side chain of arginine is properly protected by Pbf group.The purity is 95-99%. 

Product Name:  Fmoc-Arg(Pbf)-OH                                                                                                 HPLC data of Fmoc-Arg(Pbf)-OH

Fmoc-Arg(Pbf)-OH CAS No. : 154445-77-9                                                  

Molecular Formula : C34H40N4O7S   

Fmoc-Arg(Pbf)-OH Molecular Weight : 648.77   

Appearance: White to off-white powder   

Optical Rotation (25/D)  :-5.5±1.5o (c=1, DMF)   

TLC: One Spot   

Fmoc-Arg(Pbf)-OH MSDS: available

Identity  IR identical to reference   

Water Content (KF) ：0.87%  

Fmoc-Arg(Pbf)-OH Solubility：Clear colorless solution (5% m/V in DMF)

-- 20 Popular Fmoc Protected Amino acids In stock with Best Rate --

Fmoc-Ala-OH                35661-39-3                                        Fmoc-Arg(Pbf)-OH           154445-77-9

Fmoc-Asn(Trt)-OH        132388-59-1                                      Fmoc-Asp(OtBu)-OH         71989-14-5

Fmoc-Cys(Trt)-OH        103213-32-7                                       Fmoc-Gln(Trt)-OH             132327-80-1

Fmoc-Glu(OtBu)-OH     71989-18-9                                        Fmoc-Gly-OH                    29022-11-5

Fmoc-His(Trt)-OH         109425-51-6                                      Fmoc-Ile-OH                     71989-23-6

Fmoc-Leu-OH               35661-60-0                                        Fmoc-Lys(Boc)-OH           71989-26-9

Fmoc-Met-OH               71989-28-1                                       Fmoc-Phe-OH                   35661-40-6

Fmoc-Pro-OH               71989-31-6                                        Fmoc-Ser(tBu)-OH            71989-33-8

Fmoc-Thr(tBu)-OH       71989-35-0                                         Fmoc-Trp(Boc)-OH            143824-78-6

Fmoc-Tyr(tBu)-OH        71989-38-3                                        Fmoc-Val-OH                    68858-20-8

** Discount policy: Omizzur has regular discount on wholesale quantity. Periodic and regular purchasing will save a lot of costs.

Fmoc-Arg(Pbf)-OH Supply from Omizzur ltd

1. Peptides in the form of lyophilized powder provided can be stably transported under normal temperature through sealed packaging. Peptides requiring long-term preservation shall be stored in a sealed container containing desiccant in the form of lyophilized powder and stored at a temperature below - 20 centigrade, which can avoid peptide degradation, bacterial degradation and oxidation, and the formation of secondary structure of peptide.

3. The dissolved peptide is much more unstable than the lyophilized form.The peptide in the form of solution should be dissolved in the sterile water of pH 5-7(or filter with 0.2 μ m membrane) and stored at - 20 centigrade. Stored in small amount respectively to avoid repeated freezing and dissolve of them.

4. Shipping: Deliver to worldwide by Fedex / DHL  （Free shipping for orders over a certain amount. Quality analysis report (COA,MS,HPLC) ,Other corresponding analysis reports.

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