|Product name||Size||Unit price||Inventory|
|OMI06945||200mg||$ 320.00||Ready to Ship|
|OMI06945||1g||$ 830.00||Contact us|
Semaglutide is the most important receptor agonist of GLP-1 and has 94% sequence homology with human GLP-1. In the clinical treatment of diseases, GLP-1 receptor can be activated to stimulate the secretion of human insulin. Therefore, in the clinical treatment of type 2 diabetes, the GLP-1 receptor agonist Semaglutide is a scientific therapeutic agent. At present, it is generally believed that the long-term mechanism of Semaglutide is based on the modification of its structure. Among them, aminoisobutyric acid can have an ideal effect of increasing stability and avoiding the occurrence of drug degradation. Compared with traditional drugs, the drug can form a stable combination with albumin, so it can ensure the molecular weight of the drug and prolong the half-life of the drug in the human body.
The main metabolic pathway of Semaglutide is fatty acid side chain β- Oxidation will be eliminated with human excreta, but some drug prototypes will still be eliminated with the urine of patients. In addition, Semaglutide has ideal safety and tolerability characteristics. After medication, the most common adverse reaction of patients is gastrointestinal reaction, and most of the symptoms will naturally relieve, so it has the advantage of medication safety.
Solid phase reactor is required in the production of Semaglutide API. Omizzur adopts a new type of special solid phase reactor for Semaglutide, including reactor shell, air inlet pipe, air outlet pipe, gas distribution component and solid phase catalytic component. In the production process of Semaglutide product itself, the equipment of the invention is suitable for solid phase catalytic reaction, which improves the reaction effect, shortens the reaction time, and is suitable for the production of Semaglutide, making the final product more pure. When the device of the invention is used to produce Semaglutide API, the overall reaction time is reduced by 20% ‑ 30%; At the same time, the production cost of the whole process is reduced, making the cost reduced by about 10%, which is suitable for promotion and use, and promoting the further research and development of Semaglutide.
There are many impurities in the crude product of solid phase synthesis of Semaglutide that affect the purity and yield of the sample. At present, there are many studies on the purification of Semaglutide, and the purity can reach more than 99%. However, the solubility of the finished product obtained by the existing purification methods is not good, and other means are needed to improve the solubility of the finished product in the subsequent research and application process. Omizzur uses the latest peptide purification technology. The purity of the finished product reaches 99%, and the single impurity is less than 0.2%. At the same time, the solubility of the finished product is good, and the sample recovery rate can reach 100%. This process is stable and controllable, suitable for industrial production, and it can effectively reduce your scientific research or industrial needs.
Product name: Semaglutide (API) CAS:910463-68-2
Molecular Formula ：C187H291N45O59 Molecular Weight: 4113.58
|Appearance||White or almost white powder||White loose powder|
|Water content (K.F)||NMT 10.0%||4.86%|
|Related substances I (HPLC)|
Impurity A: NMT 0.3%
Impurity D: NMT 0.3%
Impurity E: NMT 0.1%
Any individual impurity: NMT 0.1%
Total impurities :NMT 1.5%
Any individual impurity:0.06%
|Related substances II(HPLC)|
Impurity B: NMT 0.3%
Impurity C: NMT 0.3%
|Specific optical rotation[a]20/D||-15.0 oto -10.0 o||-14.9o|
|Molecular ion mass||4133.58 ±1.0||Conforms|
|High molecular protein||NMT 0.5%||0.03%|
Methylene chloride NMT 600ppm
Acetonitrile NMT 410ppm
Methanol NMT 3000ppm
DMF NMT 880ppm
Isopropyl ether NMT 5000ppm
Isopropanol NMT 5000ppm
|Bacterial Endotoxins||NMT 50EU/mg||Conforms|
TAMC NMT 200cfu/g
TYMC NMT 100cfu/g
|Acid group ions|
Trifluoroacetate ion NMT 0.1%
Phosphate ion NMT 0.1%
Chloride ion NMT 0.1%
Acetate ion NMT 0.1%
|Storage||Preserve in tight containers.Store at a temperature -15.oC to -25oC|
1. For all batches of products, we will keep samples after one year of validity. When customers raise objections, we can make a quick response.
2. For the products purchased by customers, an original of our inspection report will be attached with the goods, including batch number, date, etc.
3. For custom peptide synthesis price list please feel free to contact us and we will help you solve them as soon as possible.
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2. Omizzur is a professional amino acids & peptide manufacturer, there will be a huge discounts for bulk purchase. Distributors are welcomed.
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