What is Protected amino acid
  • Protected amino acid is refers to the amino acid derivatives whose functional groups react with other groups and seal off the activity of functional groups of amino acids. The blocked groups include amino and carboxyl groups and side chain functional groups.


    Sources and manufacturing methods of amino acids

    It mainly includes protein hydrolysis, microbial fermentation, enzyme engineering and chemical synthesis.

    Amino acid synthesisProtein hydrolysisMicrobial fermentationEnzyme engineeringChemical synthesis

    • Rich raw materials  

    • Simple operation

    • L-amino acids production

    • Rich raw materials

    • L-amino acids production

    • Simple Workmanship

    • Short production cycle

    • High product concentration

    • High yield

    • Unlimited variety of amino acids produced

    • Non natural amino acids with special structure avaiilable


    • Low yield

    • High cost

    • Large environmental pollution

    • Low concentration

    • Long growth cycle

    • Limited by substrate and enzyme sources• DL amino acids need further separation

    What are the amino acid products that Omizzur can produce in large-scale? 

    Omizzur has the best variety of protected amino acids,with an annual production capacity of 100 tons.Omizzur amino acid production base can carry out addition, substitution, oxidation-reduction , rearrangement , ammonolysis, hydrogenation,alkylation,esterification and hydrolysis reaction.The main advantages are as follows:

      Amino acid protectant

    √  Coupling Reagents

    √  Linker

      Amino acid and its derivatives

    √  Unusual Amino Acids

    √  PseudoProline Dipeptides 

      Amino alcohol


    Amino acid protecting group

    The protection of amino acids is very important in peptide synthesis, which directly determines the key to the success of peptide synthesis. Many of the common 20 amino acids have active side chains and need to be protected. It is generally required that these protecting groups are stable in the synthesis process without side reactions, and can be completely quantitatively removed after the synthesis.


    The amino acids that need to be protected in synthesis include: Cys, Asp, Glu, His, Lys, Asn, Gln, Arg, Ser, Thr, Trp, Tyr.

    Groups to be protected: hydroxyl, carboxyl, mercapto, amino, guanidine, indole, imidazole, etc

    Amino CarboxylHydroxySulfydrylAcylamino
    Amino acid protecting group

    • Boc

    • fmoc

    • cbz

    • trt

    • tfa

    • OFM

    • Otbu

    • OBzl

    • OAll

    • OMe

    • TMS-OR

    • TBDMS-OR

    • TIPS-OR

    • Bn-OR

    • DTT

    • 2-Mercaptoethanol

    • Tfa

    • Pht

    • Tos

    What are the classifications of common amino acids?

    Nonpolar amino acidsAla,Val,Leu,Ile,Pro,Phe,Trp,Met
    Polar amino acidsNeutral amino acidGly,Ser,Thr,Cys,Tyr,Asn,Gln
    Basic amino acidLys,Arg,His
    Acidic amino acidAsp,Glu