CDI reagent (N,N'-Carbonyldiimidazole)

CDI coupling reagents | N,N'-Carbonyldiimidazole | CAS:530-62-1
* For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

CDI (N,N'-Carbonyldiimidazole)

Purity % (HPLC)98.5%
TypePeptide Coupling Reagent
InventoryIn stock
Price50g / $ 60.0
DeliverFedEx / DHL / EMS
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General Description

High purity CDI coupling reagents | N,N'-Carbonyldiimidazole | CAS:530-62-1

N. N-Carbodiimidazole (CDI) is mainly used as formyl transfer reagent and carboxylic acid activation reagent in organic synthesis. Because of its high reactivity, low cost and simple post-treatment, the reagent has higher application value than DCC and EDC.


The carbonyl group in CDI molecule is activated by imidazole and has very high formylation activity. When the reagent encounters hydroxyl group or amino group with active hydrogen, it can lose two imidazoles to form carbonyl derivatives at the same time according to the reaction conditions, and it can also lose one imidazole to form N-imidazole formyl ester or N-imidazole formamide. The resulting N-imidazole formyl compound can undergo further reaction to displace another imidazole to form a carbamide derivative with asymmetric structure.

Product Data Sheet

Product NameCDI (N,N'-Carbonyldiimidazole)
CAS No.530-62-1
Molecular FormulaC7H6N4O
Molecular Weight162.15
AppearanceWhite to off-white powder
Purity (HPLC)98% min.
Melting Point115~122 oC (dec.)
TLC Analysis  One spot
300 MHz 1HConsistent
Loss on Drying< 0.5%

Shipping & Storage

Storage :Keep in cool and dry place; easy to decompose when meeting with water.

Packing :100g / bottle; 500g / bottle; 1kg / bag; 2kg / bag; 20kg / barrel

Ordering Guide:

1. Staab, H. A.; Wendel, K. Org. Synth., 1968, 48, 44.

2. Kishikawa, K.; Nakahara, S.; Nishikawa, Y.; Kohmoto, S.;Yamamoto, M. J. Am. Chem. Soc., 2005, 127, 2565.

3. Nyangulu, J. M.; Galka, M. M.; Jadhav, A.; Gai, Y.; Graham,C. M.; Nelson, K. M.; Cutler, A. J.; Taylor, D. C.; Banowetz,G. M.; Abrams, S. R. J. Am. Chem. Soc., 2005, 127, 1662.

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