HOBt ,1-Hydroxybenzotriazole | CAS 2592-95-2

HOBT (1-Hydroxybenzotriazole) is a common amide condensing agent, which forms amide from organic acid and amine.The structure of HOBt is a benzotriazole structure, so it is water-soluble but not high, that is, slightly soluble. Generally, the reaction process does not use aqueous phase, and generally uses non-aqueous solvents, such as tetrahydrofuran and dichloromethane.

Because HOBt has triazole structure, it can be dissolved in inorganic acid aqueous solution. In addition to formic acid and acetic acid, organic acids can also be used as solvents. Most other organic acids are solid at room temperature and are generally not solvents.HOBT peptide condensers are widely used in peptide condensation reactions with carbodiimide condensers, which can significantly reduce the racemization ratio and prevent racemization during peptide fragment condensation.

Name:HOBT (anhydrous)

Other name: N-Hydroxybenzotriazole ; 1-Hydroxybenzotriazole

CAS 2592-95-2

Molecular formula: C6H5N3O

Molecular weight: 135.1234

Melting point: 156-159 ℃

Boiling point: > 344.6 ° C at 760 mmHg

The flash point is 162.2 ° C

The vapor pressure is less than 3.28e-05mmhg at 25 ° C

Physicochemical properties: melting point 156-159 ° C

White crystalline powder

Application: the intermediate and peptide protector of ubenimex

Popular Peptide Coupling Reagents

1. Peptides in the form of lyophilized powder provided can be stably transported under normal temperature through sealed packaging.Peptides requiring long-term preservation shall be stored in a sealed container containing desiccant in the form of lyophilized powder and stored at a temperature below - 20 centigrade, which can avoid peptide degradation, bacterial degradation and oxidation, and the formation of secondary structure of peptide.

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