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Osteoporosis is a systemic bone disease characterized by decreased bone mass and increased brittleness caused by the damage of bone microstructure. With the aging of the world population, it has become a serious social problem. According to pharmacology, osteoporosis drugs are mainly bone resorption inhibitors and bone formation promoters.
Teriparatide is a recombinant human parathyroid hormone (PTH) analogue (rhpth[1-34]) composed of 34 amino acids. It can regulate bone metabolism, renal tubular reabsorption of calcium and phosphorus, and intestinal calcium absorption. It is suitable for the treatment of osteoporosis with high fracture risk in postmenopausal women and osteoporosis with high fracture risk induced by continuous glucocorticoid treatment
The amino acid sequence of teriparatide is composed of 34 conventional amino acids, with a large number of amino acids, forming a certain secondary structure. Fragment condensation strategy is adopted to reduce the preparation difficulty. The tripathide was divided into 4 fragments, 4 using Royal resin as the solid-phase carrier, and the other fragments using 2-clctc-resin as the solid-phase carrier to synthesize the peptide resin. After 1 ~ 3 peptide resins were cleaved to the fully protected peptide, they were successively condensed to the peptide resin according to the peptide sequence, Finally, after TFA cleavage, side chain protection group removal and purification, teriparatide (scheme1) was obtained. The purity was more than 99% and the overall yield was 33%. Its structure was confirmed by MS (ESI). This method shortens the synthesis cycle, simplifies the operation of solid-liquid phase synthesis, avoids the use of unconventional amino acids, and has a high yield, which is convenient for industrial production.
Omizzur also provides custom peptide synthesis of a series of teriparatide impurities.
Product Data Sheet
Name: Teriparatide acetate
Synonym: Parathar acetate; hPTH 1-34 (acetate salt)
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shipping & Storage
It is valid for at least one year if stored at -20 ℃ or lower. Since each freezing and thawing of polypeptide will cause partial inactivation, after the storage solution with corresponding concentration is prepared for the first time (please prepare the storage solution according to the information in the column of reconstitution in the product introduction), it must be frozen at -20 ℃ or lower after sub packaging to avoid repeated freezing and thawing.
Shipping: By air or FedEx Express, delivery time: 5-10 days
Matters needing attention:
This product is freeze-dried powder. Since a small amount of polypeptide is deposited in the tube during the freeze-drying process, forming a very thin or invisible polypeptide layer, before opening the tube cover, we recommend centrifuging about 8000-12000g in a centrifuge for 10-30 seconds to make the polypeptide attached to the tube cover or tube wall gather at the bottom of the tube.
This product is only used for scientific research by professionals, and shall not be used for clinical diagnosis or treatment, food or drugs, or stored in ordinary houses.
For your safety and health, please wear lab clothes and disposable gloves.
1. For all batches of products, we will keep samples after one year of validity. When customers raise objections, we can make a quick response.
2. For the products purchased by customers, an original of our inspection report will be attached with the goods, including batch number, date, etc.
3. If you have any problems in use, please feel free to contact us and we will help you solve them as soon as possible.
1. After you confirm the purchase, please inform our sales staff of your detailed requirements, including product name, quantity, packaging requirements, etc., as well as your receiving address, company name and contact information; Then our sales staff will make an order for you.
2. Omizzur is a professional peptide manufacturer, there will be a huge discounts for bulk purchase. Distributors are welcomed.
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