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Sermorelin acetate, also known as GHRH (1-29), is a peptide analogue of growth hormone releasing hormone (GHRH) used as a diagnostic agent for evaluating growth hormone (GH) secretion and for diagnosing growth hormone deficiency. It is a peptide of 29 amino acids, representing the 1-29 fragments from endogenous human GHRH, and is considered the shortest fully functional fragment of GHRH.

Sermorelin essentially mimics the hypothalamic peptide GHRH. And it directly acts on the pituitary gland, stimulating the ability of growth hormone cells to produce and secrete GH. Sermorelin can affect the synergistic effect of hormone signals that affect the GH axis.

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Mechanism of action of Sermorelin 

Sermorelin is a synthetically produced 29-amino acid polypeptide growth hormone-releasing factor, which is the N-terminal fragment of endogenous growth hormone-releasing hormone (GHRH) and exhibits significant growth-regulating effects. It is proposed that neuropeptides/neurotransmitters, hormones, and cytokines serve as the "common language" for mutual regulation among the nervous, endocrine, and immune systems. In addition to its highly refined intrinsic regulatory mechanisms, the immune system is also modulated by the neuro-endocrine-immune network.

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Sermorelin acts on the growth hormone-releasing hormone receptor (GHRHr) in the pituitary gland to regulate cellular activity. GHRHr is the natural receptor for the endogenous hormone growth hormone-releasing hormone (GHRH), a signaling hormone produced by the hypothalamus. This receptor primarily controls the release of growth hormone by inhibiting somatostatin activity, among many other functions.

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Sermorelin Safety Statement

For scientific research purposes only: not suitable for clinical, diagnostic, or therapeutic use on the human body; Non dietary supplements/drugs

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