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AOD-9604 is a synthetic peptide fragment derived from the C-terminal sequence of human growth hormone. The peptide corresponds to amino acids 176-191 of the complete growth hormone molecule, and a tyrosine residue is added to enhance its stability.

AOD-9604 was originally developed by researchers in the late 1990s, aiming at separating the part of growth hormone responsible for fat metabolism, especially stimulating lipolysis and inhibiting lipogenesis, while avoiding the systemic endocrine effects associated with the administration of intact growth hormone. Preclinical studies in obese animal models show that AOD 9604 can reduce weight gain, increase lipid oxidation and enhance lipolysis sensitivity, which are related to the increase of lipolysis receptor expression in adipose tissue.

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AOD-9604 does not bind to or activate the traditional growth hormone receptor, nor does it stimulate the secretion of insulin-like growth factor -1, which makes its activity different from that of intact growth hormone. In rodent studies, long-term administration of AOD 9604 can lead to body fat loss and increase of lipid oxidation markers, without causing hyperglycemia or increased insulin secretion, which are common side effects of growth hormone therapy. These findings emphasize the potential of AOD 9604 as a targeted regulator of adipose tissue metabolism, rather than a general anabolic agent.

In terms of mechanism, the effect of AOD-9604 on fat metabolism is still under study. Preclinical model showed that the peptide interacted with adipose tissue signaling pathway, which enhanced lipolysis and lipid oxidation. Although the early hypothesis suggested that its function involved β -adrenergic receptor, the subsequent research in the receptor gene knockout model showed that the function of the peptide did not depend entirely on a single receptor pathway, which meant that it had a broader regulatory effect on adipose tissue metabolism.

In a word, AOD-9604 is a targeted peptide fragment derived from human growth hormone, which shows promising fat metabolism in animal research and is well tolerated in early human trials.

However, the lack of consistent evidence of therapeutic effectiveness in weight loss clinical trials limits its development as an approved therapy. At present, its main value lies in the research field, as a tool to explore the regulatory mechanism and metabolic signal pathway of adipose tissue which is different from the classical growth hormone activity.

At present, researchers are still exploring its potential applications in cartilage repair and metabolic regulation, but these applications are still in the experimental stage.

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ScientificResearch Use of AOD-9604 (in vitro/animal experiments only)

1. Obesity and metabolism research: Weight loss and fat loss in diet/genetic obesity model are used for obesity mechanism, lipid metabolism regulation and anti-obesity drug screening.

2. Study on metabolic syndrome: Improve insulin sensitivity and regulate glucose and lipid metabolism, and use it in the intervention study of type 2 diabetes and nonalcoholic fatty liver (NAFLD).

3. Cartilage/bone repair research: promote chondrocyte proliferation and matrix synthesis, and use it in animal experiments and tissue engineering of osteoarthritis and joint injury repair.

4. Energy homeostasis and signaling pathways: To study the role of β3-AR, HSL, AMPK and other pathways in fat metabolism, and explore the GH-independent weight regulation mechanism.

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