Thymosin alpha-1 raw materials powder CAS 62304-98-7 Fast Shipping Worldwide

Thymosin Alpha-1 (Thymosin α1), also known as thymosin or thymopeptide 28, is a chemical with a molecular weight of 3108.3 and needs to be stored at-20 C. It is mainly used as immunomodulator and peptide experiment in clinic.

Thymosin α1 is a chemically synthesized thymosin α1, which is the same as human thymosin α1. Thymosin α1 is an acetylated peptide. Thymosin α1 is currently approved for the treatment of hepatitis B and C in 35 developing countries. At the same time, thymosin α1 is used to improve the immune response of other diseases.

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The Core Mechanism of Thymosin Alpha-1

1. Congenital immune regulation (the first line of defense)

Congenital immunity is the body's first line of defense against pathogens and tumors, and Thymosin Alpha-1 can fully activate the function of innate immune cells.

2. Adaptive immune regulation (core therapeutic effect)

Adaptive immunity is the core system to specifically remove pathogens and tumor cells, and it is also the core pharmacological target of Thymosin Alpha-1.

3. Direct and indirect antiviral effects

Thymosin Alpha-1 has a significant inhibitory effect on a variety of DNA and RNA viruses, and it is one of the first-line treatment drugs for chronic hepatitis B.

4. Anti-tumor effect

Thymosin Alpha-1 is the most commonly used immunotherapy drug in tumor radiotherapy and chemotherapy, targeted therapy and immunotherapy.

5. Antioxidant stress and cell protection

Up-regulating the expression and activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx), scavenging reactive oxygen species (ROS), inhibiting lipid peroxidation and protecting cells from oxidative stress damage.

6. Anti-inflammatory and immune homeostasis maintenance

Maintaining the body's immune homeostasis, enhancing the immune defense function when the immunity is low, inhibiting abnormal inflammatory reaction when the immunity is over-activated, and realizing two-way immune balance adjustment, which are the core advantages different from traditional immune enhancers and immunosuppressants.

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Application of Thymosin Alpha-1 in scientific research field

Immunobiological research: As a classic tool peptide for T cell development, differentiation and immune regulation, it is used for basic research of innate immunity and adaptive immunity.

Anti-virus and anti-tumor immunity research: mechanism research on virus infection and tumor immune microenvironment, and research and development of new immunotherapy drugs.

Thymus function and immune aging research: it is used for the basic and transformation research of thymus development and immune aging mechanism, and is a classic model molecule in the field of aging immunology.

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Suggestions on dissolution and preservation of Thymosin alpha-1

Dissolution method

Good water solubility, can be directly dissolved in sterile water for injection or PBS buffer (pH7.0-7.4), and the solubility is ≥40mg/mL.

If turbidity occurs during high concentration dissolution, 0.1M NaOH solution can be added drop by drop to adjust the pH to 7.0-7.5 to assist dissolution.

Storage condition

Freeze-dried powder status: -20℃ dry and dark storage, valid for 36 months.

Solution state: it can be stored stably for 30 days at 4℃ and protected from light. After long-term storage, it needs to be packaged and frozen at -20℃. After repeated freezing and thawing for more than 15 times, the activity has not decreased significantly.

In vivo experiments suggest that it is now used without adding protease inhibitors.

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