CJC-1295 (DAC) Raw Materials Peptide Powder High Purity

CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analog, and CJC-1295 is composed of 30 amino acids. The first 29 amino acids of GHRH are active segments, which are provided in the form of artificial peptide Sermorelin. Sermorelin was further modified to extend its half-life to 30 minutes. This is called CJC 1295. CJC-1295 is further modified by adding DAC (drug affinity complex) to it.

The core structure of CJC-1295 is based on the first 29 amino acid fragments of human GHRH. By linking the 27th lysine residue with maleimide caproic acid linker(DAC modification group), it can reversibly bind to serum albumin, thus prolonging the circulating time in vivo.

CJC-1295 is an peptide hormone for increasing the production of growth hormone (GH). The structure of this peptide is similar to that of growth hormone releasing factor (GHRH), so it works in the same way as GHRH.

>> Omizzur lab is available in two versions: CJC1295 DAC and without DAC.

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What is the difference between CJC 1295 DAC and CJC 1295 (without DAC decoration)?

A: The core difference between them lies in whether they contain DAC modifying groups: CJC1295 DAC (CAS: 446262-90-4) contains DAC groups, which can reversibly bind with serum albumin, and its half-life is as long as 6-8 days. It is a long-acting preparation, and it can be administered once or twice a week. CJC 1295 (without DAC) has no such modification, and its half-life is only 30 minutes to 2 hours. It is a short-acting preparation and needs to be administered 2-3 times a day.

In addition, there is a slight difference in the number of amino acids between them. CJC 1295 DAC is 30 amino acids, and CJC 1295 (without DAC) is 29 amino acids, with molecular weights of about 3647.18 and 3400 respectively. The experimental use should be selected according to the frequency of administration and experimental requirements.

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Q: What effect does the purity of CJC 1295 DAC have on the experiment? How to ensure the purity of experimental samples?

A: Purity directly affects the accuracy and repeatability of the experimental results. Too many impurities may interfere with the experimental reaction and even lead to the failure of the experiment (for example, impurities may react with experimental reagents and affect the biological activity of peptides).

The key to ensure the purity is to select the products produced by regular manufacturers and check the HPLC purity test report of the products; The purity can be detected by HPLC again before use to ensure that it meets the experimental requirements; Strictly control the conditions in the process of storage and dissolution to avoid the degradation of peptides to produce impurities.

Q: What is the best storage condition for CJC 1295 DAC? How to avoid failure during storage?

Answer: The best storage conditions are frozen at -20℃, sealed, protected from light and dried to avoid repeated freezing and thawing (repeated freezing and thawing will destroy the spatial structure of peptides and lead to loss of activity); Short-term (1-2 weeks) can be stored at 2-8℃ without freezing.

CJC 1295 DAC should be stored separately from oxidants, strong acids, strong bases and other substances to avoid contact with humid environment and prevent peptide hydrolysis and oxidative degradation. It should be used as soon as possible after opening, and the unused part should be resealed and frozen at -20℃. The shelf life is usually 12-24 months (refer to the product manual for details)

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About Omizzur Ltd

Omizzur specializes in custom peptide synthesis, providing professional peptide synthesis services to pharmaceutical R&D companies worldwide. Our product offerings include pharmaceutical-grade peptides, cosmetic peptides, peptide impurity synthesis, and amino acid derivatives. For more peptide product information, please contact Omizzur custom peptide synthesis.