Melittin (synthetic)

Melittin CAS 20449-79-0 | Omizzur
* For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Name

Melittin

TypeAnti inflammatory / anti-tumor
CAS

20449-79-0

Purity % (HPLC)> 95.0% (HPLC)
Pack size

Price ( USD )

Inventory
100mg$  /
In stock
1 gPlease inquire
In stock
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General Description

Melittin CAS 20449-79-0 

Cancer is still one of the most terrible diseases threatening human life. At present, the treatment methods for cancer have made some achievements in some early and middle stage cancers, and the curative effect for cancer with metastasis or recurrence is not good. In a wide range of studies, bee venom has shown anti-cancer effects in a variety of malignant tumors, and bee venom peptide is the main active component and anti-tumor component of bee venom


Melittin is the most important polypeptide in bee venom, which consists of 26 amino acid residues. It has a wide range of pharmacological effects and high biological activities. It can not only be used to treat arthritis, rheumatism, pain, neurodegeneration, skin diseases and other diseases, but also has good anti-tumor activity. It shows therapeutic effect on more than 60 different types of human cancer cells. It can not only directly kill tumor cells by destroying the phospholipid bilayer of cell membrane, but also inhibit tumor angiogenesis, induce tumor cell apoptosis, participate in immune regulation, inhibit tumor cell proliferation, invasion The ability of migration interferes with the biological behavior of tumor tissue and plays an anti-tumor role.


Melittin has a variety of targets, complex mechanisms, and is not easy to produce drug resistance. It shows different action pathways when it plays a role in different types of tumor cells, and shows good synergistic effects with radiotherapy, chemotherapy and targeted therapy. It is expected to alleviate the pressure caused by chemotherapy and targeted therapy drug resistance and radiotherapy resistance. Melittin can also participate in immune regulation and activate the body's immune response to help fight tumors. The application of melittin has been greatly improved by the research on the molecular structure modification or modification of melittin, the mode and route of administration, and the delivery system.


Product Data Sheet

NameMelittin  (synthetic)
CAS20449-79-0
SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Molecular FormulaC131H229N39O31
Molecular Weight2846.5
Purity95% (HPLC)
SpecificationSalted / desalted
Form
lyophilized powder
Storage
-20o


Shipping & Storage

It is valid for at least one year if stored at -20 ℃ or lower. Since each freezing and thawing of polypeptide will cause partial inactivation, after the storage solution with corresponding concentration is prepared for the first time (please prepare the storage solution according to the information in the column of reconstitution in the product introduction), it must be frozen at -20 ℃ or lower after sub packaging to avoid repeated freezing and thawing.

Shipping: By air or FedEx Express, delivery time: 5-10 days


Matters Needing Attention:

This product is freeze-dried powder. Since a small amount of polypeptide is deposited in the tube during the freeze-drying process, forming a very thin or invisible polypeptide layer, before opening the tube cover, we recommend centrifuging about 8000-12000g in a centrifuge for 10-30 seconds to make the peptide attached to the tube cover or tube wall gather at the bottom of the tube.

This product is only used for scientific research by professionals, and shall not be used for clinical diagnosis or treatment, food or drugs, or stored in ordinary houses.

For your safety and health, please wear lab clothes and disposable gloves.


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