Tirzepatide API CAS 2023788-19-2 | Tirzepatide raw material powder

Tirzepatide is a novel hypoglycemic peptide that activates dual channel receptors (GLP-1 and GIP) to effectively control blood sugar and assist in weight loss. Its mild effect and low risk of hypoglycemia are suitable for eligible patients with type 2 diabetes. Tirzepatide is an innovative weight loss drug that simulates the combined action of two intestinal hormones, which can control appetite and improve metabolism.

Tirzepatide API Synthesis

Tirzepatide API a linear peptide composed of 39 amino acids, the synthesis process of Omizzur's Tirzepatide API is mainly a solid-liquid mixing method, and its structural design is based on partial structures of GLP-1, GIP, and exenatide, as well as the addition of unique amino acids. Firstly, 4 fragments were synthesized using liquid-phase synthesis method, and then the four fragments were docked and synthesized using solid-phase synthesis method to complete the crude product of tilpotide. This method can effectively balance production efficiency and product purity, and is currently the mainstream solution for industrial production of Tirzepatide  API.

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What breakthroughs have been made in the latest research field of Tirzepatide?

The clinical data of the self exemption track is impressive: In June 2026, Eli Lilly announced the complete data of two Phase III clinical studies on the treatment of psoriatic arthritis and psoriasis with tilpotide at the European Rheumatology Congress. The combination therapy was significantly better than the monotherapy group in improving joint symptoms and clearing skin lesions, and only regulatory approval was needed before it was officially approved for self exemption indications.

The cardiovascular benefit mechanism is clear: The SUMMIT trial and its sub analysis have confirmed that tilpotide can significantly reduce the risk of death in obese heart failure patients with preserved ejection fraction by 38%, improve cardiac structure and function, and alleviate end-stage organ damage to the heart and kidneys.

Diabetes prevention effect is significant: long-term follow-up data show that for obese people with pre diabetes, the risk of progression to type 2 diabetes can be reduced by 94% after 176 weeks of treatment with tilpodide, and the risk is still lower than that of the placebo group after drug withdrawal.

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About Omizzur Ltd

Omizzur specializes in custom peptide synthesis, providing professional peptide synthesis services to pharmaceutical R&D companies worldwide. Our product offerings include pharmaceutical-grade peptides, cosmetic peptides, peptide impurity synthesis, and amino acid derivatives. For more peptide product information, please contact Omizzur custom peptide synthesis.