Semaglutide API CAS  ‌910463-68-2‌ | Semaglutide raw material powder

Semaglutide, a GLP-1 receptor agonist, is mainly used to treat type 2 diabetes and obesity. It simulates the action of GLP-1 hormone in the human body, delaying gastric emptying, promoting insulin secretion, and suppressing appetite, thereby helping to control blood sugar and lose weight.

Semaglutide API Synthesis

The basis of Semaglutide synthesis is solid-phase peptide synthesis, which allows researchers to connect amino acid units one by one from the C-terminus until a complete peptide chain is formed. Compared with natural GLP-1, Semaglutide has been modified at several key sites to enhance its enzymatic stability and in vivo half-life: the most crucial point is to replace Ala in the second amino acid with Aib (α - aminoisobutyric acid) to enhance resistance to DPP-4 enzyme degradation. In addition, by connecting a long-chain lipophilic side chain (C18 fatty acid) to a hydrophilic linker at the Lys26 site, the affinity for binding to albumin was effectively enhanced, prolonging the duration of drug efficacy.

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What breakthroughs have been made in the latest research field of Semaglutide?

It is worth noting that the benefits of semaglutide go far beyond that. As a GLP-1 receptor agonist, it was originally widely used in the treatment of diabetes to control blood glucose levels by promoting insulin secretion, inhibiting gastric emptying and other ways. And this study found that semaglutide also showed good therapeutic effects in HIV infected individuals, further expanding its clinical application scope.

In addition, the study observed that patients taking semaglutide also improved their overall health status. For example, their physiological indicators such as lumbar muscle strength, sitting time, and walking speed were significantly improved, indicating that semaglutide may also have the potential to improve physical function and enhance quality of life.

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