Terlipressin

Terlipressin CAS 14636-12-5 | Omizzur
* For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Name

Terlipressin

TypeVasopressin analogue
CAS

14636-12-5

Purity % (HPLC)> 98.0% (HPLC)
Pack size

Price ( USD )

Inventory
100mg$  /
In stock
1 gPlease inquire
In stock
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General Description

Terlipressin CAS 14636-12-5

Terlipressin is a drug similar to the natural hormone in the body, called antidiuretic hormone (ADH) or vasopressin. ADH has two main functions in vivo. First, it causes blood vessels to narrow (constrict), limiting blood flow to specific areas of the body. It also acts on receptors in the kidneys to retain water in the body, which helps prevent excessive loss of water in the urine


Terlipressin study:

Terlipressin is an analog of vasopressin, which acts on three different receptors, vasopressin receptor V1a (initiating vasoconstriction, hepatic gluconeogenesis, platelet aggregation and factor VIII release), vasopressin receptor V1b (mediating pituitary adrenocorticotropic hormone secretion) and vasopressin receptor V2, which controls the free water reabsorption of renal medulla. Terlipressin binding to the V2 receptor activates adenylate cyclase, resulting in the release of aquaporin 2 channels into the renal medullary canal lining cells. This allows the water to be reabsorbed under the osmotic gradient, which makes the urine more concentrated.


Terlipressin application:

Terlipressin is an antihypertensive drug used to treat acute or chronic vascular hypertension, regardless of its pharmacological mechanism. Antihypertensive drugs include diuretics; (especially diuretics, thiazides); Adrenergic β Receptor antagonists; Adrenergic α Antagonists; Angiotensin converting enzyme inhibitor; Calcium channel blockers; Ganglionic blockers; And vasodilators.



Product Data Sheet

NameTerlipressin
CAS14636-12-5
SequenceH-Gly-Gly-Gly-Cys(1)-Tyr-Phe-Gln-Asn-Cys(1)-Pro-Lys-Gly-NH2,(Cys4-Cys9)
Purity %98% min
Molecular formulaC52H74N16O15S2
Molecular weight1227.4
TypeVasopressin analogue
SourceCustom peptide synthesis


Shipping & Storage

It is valid for at least one year if stored at -20 ℃ or lower. Since each freezing and thawing of polypeptide will cause partial inactivation, after the storage solution with corresponding concentration is prepared for the first time (please prepare the storage solution according to the information in the column of reconstitution in the product introduction), it must be frozen at -20 ℃ or lower after sub packaging to avoid repeated freezing and thawing.

Shipping: By air or FedEx Express, delivery time: 5-10 days


Matters Needing Attention:

This product is freeze-dried powder. Since a small amount of polypeptide is deposited in the tube during the freeze-drying process, forming a very thin or invisible polypeptide layer, before opening the tube cover, we recommend centrifuging about 8000-12000g in a centrifuge for 10-30 seconds to make the polypeptide attached to the tube cover or tube wall gather at the bottom of the tube.

This product is only used for scientific research by professionals, and shall not be used for clinical diagnosis or treatment, food or drugs, or stored in ordinary houses.

For your safety and health, please wear lab clothes and disposable gloves.


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