Fmoc-2,6-dimethyl-L-tyrosine | 206060-54-0 | Unnatural amino acids

Fmoc-2,6- dimethyl -L- tyrosine is a derivative of 2,6-dimethyl-l-tyrosine protected by Fmoc, with CAS number of 206060-54-0, molecular formula of C₂₆H₂₅NO₅, and molecular weight of 431.48. It is often used as an unnatural amino acid building block in peptide synthesis.

Structure and Use

Structural characteristics: L- tyrosine is the skeleton, two methyl groups are introduced into the 2 nd and 6 th positions of benzene ring, and the N-terminal is protected by Fmoc. Methyl substitution changes the steric hindrance and electronic properties of amino acids.

Main uses: As an unnatural amino acid building block, it can be used in solid-phase peptide synthesis (SPPS) with Fmoc strategy to construct peptides and peptidomimetics containing 2,6- dimethyltyrosine.

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Application of unnatural amino acids

Unnatural amino acids are mainly used to transform protein, and are widely used in drug research and development, vaccine production and biomaterials. ‌‌

How to use unnatural amino acids in pharmaceutical R&D

1. Make the drug effect last longer: Inserting unnatural amino acids into antibodies or protein drugs can enhance the binding force between drugs and targets and prolong the time of action in the body.

2. Accurately connecting drugs: When used in antibody-coupled drugs (ADC), it can realize fixed-point coupling between drugs and antibodies, making the drug effect more stable and the side effects less.

3. Optimize polypeptide drugs: introduce special structure into polypeptide drugs to improve stability, reduce the rate of degradation by the body, and make it convenient for patients to use.

Omizzur Peptides and Amino acids products:

Fmoc-2,6-dimethyl-L-tyrosine CAS 206060-54-0 | Omizzur Peptide

Shipping:

We ship amino acid/peptide products by Fedex/ air. If the products are in stock, the transportation time is usually about 5-10 days.

Storage:

Room Temperature (Recommended in a cool and dark place, 2-8°C)

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About Omizzur Ltd

Omizzur specializes in amino acid derivatives and peptide synthesis, providing professional peptide synthesis services to pharmaceutical R&D companies worldwide. Our product offerings include pharmaceutical-grade peptides, cosmetic peptides, peptide impurity synthesis, and unnatural acid derivatives. For more product information, please contact Omizzur custom peptide synthesis.