Peptide Knowledge Center

Antibacterial peptides can be used as drug carriers

The insect antibacterial peptide pyrrochoricin and its derivatives are said to be one of the best drug delivery carriers so far. The carrier of drug delivery must have low toxicity and cell penetration. When looking for drug carriers, cationic molecules rich in proline are often selected because they can penetrate the cell membrane. However, it is regrettable that pyrrochoricin and other molecules usually show high toxicity. Pip-pyrr-MeArg, a cationic molecular analogue rich in proline, has been further designed, and has not shown toxicity in vivo and in vitro experiments. These molecules can easily penetrate bacterial cells and even human cells, and the designed analogs can penetrate several human cells, including fibrous cells.

The carrier system can transport drugs to pathogens in cells and can be used as carriers for other drugs. The research on the scope of application of the system is ongoing. Antibacterial peptides and their analogues can also penetrate human dendritic cells (DC), which makes it a good choice for antigen-determined cluster-based vaccine vectors. Experiments show that these peptides can easily penetrate into Dc without showing toxicity, and can stimulate the immune system and activate DC. This makes it possible for the system to be used for vaccine development and anticancer therapy

Although DC vaccination is still in the early stage of research, it is a promising strategy for inducing immunity to cancer cells. The application of DC-loaded special peptide antigens in cancer immunotherapy is increasing. The efficacy of these vaccines is related to the activation of DC cells. Therefore, pyridoxorin and its analogues can stimulate the ability of Dc, making them a powerful tool for constructing polypeptide antigen vectors

from Omizzur biotech