Peptide Knowledge Center

8 kinds of impurities which appear in peptide drugs synthesis

Peptide drugs have the advantages of relatively low cost, strong biological activity, less toxic and side effects, and specific targets, so they are widely used. At present, the growth rate of the peptide drug market is twice that of other drug markets.

Most of the peptide drugs are obtained by solid-phase peptide synthesis technology. During the synthesis, storage and transportation of peptide drugs, various types of related structural impurities will be generated. Many peptide-related structural impurities not only have no drug efficacy, but have toxic and side effects, which will affect their biological functions and efficacy. Therefore, the analysis and control of related structural impurities is one of the important factors to be considered during drug development and clinical use. Here are 8 common peptide impurity categories (for custom peptide synthesis price list visit Omizzur ):

1. Amino acid deletion

2. Amino acid insertion

3. Protective group residues

4. Oxidation/Reduction

5. Diastereoisomerization

6. Side chain modification impurities

7. Terminal modification impurities

8. Aggregates