Antide acetate

Antide acetate purity99% | CAS:112568-12-4_Omizzur
* For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Name

Antide acetate

CAS

112568-12-4

Molecular formul

C82H108ClN17O14

Purity

95%,98%

Sample

available

Shipping

Fedex / DHL/ EMS

Packing specification

10mg, 50mg, 100mg or customized

Price

Please inquire

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General Description

Antide acetate is a GnRH antagonist. Gonadotropin releasing hormone antagonist (GnRH antagonist) is a synthetic peptide that competes with endogenous neurohormone GnRH (also known as luteinizing hormone releasing hormone, LHRH) in the anterior pituitary to bind to its receptor. GnRH antagonists inhibit the release of gonadotropins such as follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary by reducing or blocking the effect of GnRH.

 

The preparation of antide acetate is as follows: firstly, the peptide intermediate is treated with appropriate mercaptan to remove the NP protective group. Then it reacted with 2-benzyl-4-carboxypyridine in DMF as coupling agent in DCC to acylate 5-orn residue. After washing, the peptide resin was treated with piperidine to remove the Fmoc protective group, and then treated with nicotinic acid and diic to acylate the D-Lys residue at the 6-position. After cleavage and HPLC purification, the GnRH antagonist was tested, and it was considered that the peptide could effectively prevent ovulation in low-dose female mammals.

 

Application:antideis a GnRH antagonist for IVF patients to prevent premature LH surge.

 

Key raw materials for synthesis of antide acetate:

1.Fmoc-Lys(ipr,Boc)-OH   201003-48-7

2.Fmoc-D-Lys(Nic)-OH   252049-12-0

3.Fmoc-Lys(Nic)-OH   252049-11-9

4.Fmoc-D-Phe(4-Cl)-OH   142994-19-2

5.Ac-2-D-Nal-OH   37440-01-0

6.Fmoc-3-D-Pal-OH  142994-45-4


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Product Data Sheet

Antide acetate

CAS:112568-12-4

Molecular formula: C82H108ClN17O14

The molecular weight of antide acetate :1591.2934

Boiling point of antide: 1798 ° C at 760 mmHg

Antide density: 0 mmHg at 25 ° C

Flash point of antide: 1041.2 ° C

Shipping & Storage

Storage:-20°C(1 year) or -80°C(1~2 years)

Shipping: deliver by Fedex or DHL,free shipping for wholesale order


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