Fmoc-Lys(Pal-Glu-OtBu)-OH | CAS 1491158-62-3 | Shipping Global

Fmoc-Lys(Pal-Glu-OtBu)-OH is a pharmaceutical intermediate that can be used in the synthesis and research of Tirzepatide and Liraglutide. Omizzur supply Fmoc-Lys(Pal-Glu-OtBu)-OH in bulk and shipping worldwide.

Uses

Fmoc-Lys (Pal-Glu-OtBu)-OH is a non-cleavable antibody-drug conjugates linker capable of synthesizing antibody-drug conjugates. It can also be used as an alkyl chain-based PROTAC linker for the synthesis of PROTACs.

Application

Fmoc-Lys(Pal-Glu-OtBu)-OH is a racemic, solid-phase, industrial building block for the synthesis of peptides and polypeptides. This product is used in the synthesis of liraglutide (a peptide), which is used to treat type 2 diabetes mellitus. It is synthesized by a solid phase process using coupling reactions with an acid labile linker. This product has been shown to be an efficient building block for the synthesis of peptides and polypeptides that have a sequence that can be varied by changing the protecting group on the amino acid.

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Biological Activity

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

Fmoc-Lys(Pal-Glu-OtBu)-OH | CAS 1491158-62-3 | Global Delivery

Storage temp. 2-8°C

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