Nonapeptide-1 CAS 158563-45-2 | Global Delivery

Nonapeptide-1 is a peptide hormone that selectively antagonizes MC1R (Ki: 40 nM) by competitively inhibiting alpha MSH induced melanin synthesis. It is effectively used in research related to skin pigmentation, adrenal steroidogenesis, and skin cancer.

Nonapeptide-1 is a synthetic peptide compound consisting of 9 amino acid residues, with the sequence MP-D-Phe-R-D-Trp-FCPV-NH ₂. The molecule is capped at the end by an amide bond (- NH ₂), forming a stable peptide chain structure. Its amino acid composition includes modified D-type amino acids (such as D-phenylalanine and D-tryptophan), which may affect the stereochemical properties of the molecule, thereby regulating its interaction with biological targets.

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Application Background of Nonapeptide-1

The synthesis design of Nonapeptide-1 is usually based on the simulation or optimization of biologically active peptides. The substitution of D-type amino acids in its structure may aim to enhance metabolic stability and prolong the half-life in vivo. These peptide compounds are often explored in biomedical research as signal molecule modulators or components of targeted delivery systems.

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