Penicillin is the world's first anti infective drug used in clinical practice. For a long time, penicillin has been thriving in the antibiotic market and has become a widely used first-line antibacterial drug worldwide.

What is Penicillin?

Penicillin is a type of antibiotic, which refers to a class of antibiotics extracted from Penicillium culture medium containing penicillane, which can destroy the cell wall of bacteria and have a bactericidal effect during the proliferation period of bacterial cells. It is the first antibiotic that can treat human diseases.

Penicillin can be classified according to its characteristics into penicillin G, penicillin V, enzyme resistant penicillin, ampicillin, and anti pseudomonas penicillin. Among them, there are various types of penicillin G products, such as long-acting penicillin G, penicillin sodium, benzylpenicillin sodium, penicillin potassium, benzylpenicillin potassium, etc.

What is 6-Aminopenicillanic acid?

6-Aminopenicillanic acid (6-APA) is a type of penicillin β- The core component of lactam antibiotics. It is used as a precursor for antibacterial compounds ampicillin and amoxicillin.

6-Aminopenicillanic acid Downstream products:

Piperacillin, Carboxybenzylpenicillin, Penicillin Imipenem (monohydrate), Benzospirin Sodium, Flucloxacillin Sodium, Sulbactam Related Substances, Penicillic Acid, Sulbactam Related Substances, EMETHICILLIN, Thiazole-4-carboxylic Acid, 6 β- Phthalimidopenicillanic Acid.

6-Aminopenicillanic acid Chemical Properties

White or slightly yellow crystalline powder. Melting point 208-209 ℃ (decomposition). Slightly soluble in water, insoluble in butyl acetate, ethanol, or acetone. It decomposes when exposed to alkali and is relatively stable to acids.

6-Aminopenicillanic acid Uses

6-Aminopenicillanic acid (6-APA) can introduce different side chains to obtain various types of penicillin with different pharmacological effects. An important intermediate in the production of numerous semi synthetic penicillin antibiotics such as ampicillin and amoxicillin.

6-Aminopenicillanic acid Production Method

There are solid-phase enzyme method and chemical lysis method for 6-Aminopenicillanic acid. The chemical cracking method uses penicillin G potassium salt as raw material, undergoes condensation, chlorination, and etherification to obtain diimide ether. Then, the diimide ether is added to distilled water at 0 ° C, cooled to -13 ± Chemicalbook 1 ° C, hydrolyzed for 20 minutes, and ammonia water (with crystal seeds added midway) is added. After addition, the temperature is controlled at 13-15 ° C, and ammonium bicarbonate is added to adjust the pH to 4.1 for 20 minutes. The mixture is filtered, washed with acetone, and dried to obtain 6-APA.

6-Aminopenicillanic acid Synthesis and Price & Omizzur

Omizzur is produced 6-APA through integrated biological fermentation and is currently supplied in large quantities to pharmaceutical markets such as India and Europe.

6-Aminopenicillanic acid | CAS 551-16-6 Supply for Bulk - Omizzur

【 Storage Temperature】:  2-8 ℃

【 Characteristics 】: White or slightly yellow crystalline powder, slightly soluble in water, insoluble in butyl acetate, ethanol or acetone. It decomposes when exposed to alkali and is relatively stable to acids.

【 Melting Point 】: 208~209 (℃)

【 Dissolution 】: Slightly soluble in water, insoluble in general organic solvents.

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