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PyBOP is a relatively strong condensing agent. Generally, other condensing agents do not condense well, and PyBOP is often used to get better results. For example, PyBOP can be used to condense amino acids with ammonium chloride to obtain corresponding aminoamides.
Hexamethylphosphoramide, a by-product of BOP in peptide synthesis, has carcinogenic toxicity. So PyBOP, a condensation agent with low toxicity and high reactivity, was developed and commercialized.
Product Data Sheet
Other name :Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
Melting Point 154-156 °C (dec.)(lit.)
Water Solubility methanol: 25 mg/mL, clear
Shipping & Storage
Storage condition 2-8°C
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