Peptide Impurity Synthesis

To study the generation of impurities in peptide synthesis, the main aspects are as follows:

1. The process lacks impurities, and the solid-phase synthesis of peptides cannot be 100% condensation in every step. It is inevitable that there will be the loss of some amino acids, and the polypeptide chain itself may break, and some structures may be modified.

2. Degrade impurities. For example, some amino acids are prone to hydrolysis, oxidation or even polymerization. Ichq3 also requires the study and control of solvent residues, elemental impurities and genotoxicity. At present, when applying for polypeptide products, in addition to the first two types of impurities, the latter solvent residues, elemental impurities and genotoxic impurities should be considered.

At present, Omizzur provides customized synthesis of impurities of a series of drug peptides to facilitate your research in impurities. Some products are as follows. If you need other products, please consult our customer service personnel:


NameImpuritiesProbability

Exenatide :

H-1His-2Gly-3Glu-4Gly-5Thr-6Phe-7Thr-8Ser-9Asp-10Leu-11Ser-12Lys-13Gln-14Met-15Glu-16Glu-17Glu-18Ala-19Val-20Arg-21Leu-22Phe-23Ile-24Glu-25Trp-26Leu-27Lys-28Asn-29Gly-30Gly-31Pro-32Ser-33Ser-34Gly-35Ala-36Pro-37Pro-38Pro-39Ser-NH2

Endo-39Ser-ExenatideHigh
Endo-34Ser-Exenatide Medium
Endo-9Ser-ExenatideMedium
Endo-12Ser-ExenatideMedium
Des-4Gly-ExenatideHigh
Des-29Gly-ExenatideMedium
Des-34Gly-ExenatideMedium
……………………

Calcitonin Salmon:

H-1Cys-2Ser-3Asn-4Leu-5Ser-6Thr-7Cys-8Val-9Leu-10Gly-11Lys-12Leu-13Ser-14Gln-15Glu-16Leu-17His-18Lys-19Leu-20Gln-21Thr-22Tyr-23Pro-24Arg-25Thr-26Asn-27Thr-28Gly-29Ser-30Gly-31Thr-32Pro-NH2 (Bridge Cys1-Cys7)


Des-Thr21 Calcitonin Salmon:

High

Endo-Asn4 Calcitonin Salmon

High
Endo-Asn27 Succinamide Calcitonin SalmonMedium
Des-Pro23 Calcitonin Salmon:High

Des-Gly28 Calcitonin Salmon:

High
Des2-Ser Calcitonin SalmonHigh
Formyl Lys11 Calcitonin SalmonHigh
Formyl Lys18 Calcitonin SalmonHigh
Acetyl-Lys18Calcitonin Salmon High
……………………

Vasopressin[Asp5] vasopressinHigh
[Glu4] vasopressinMedium
[Gly9-OH] vasopressinMedium
[His2]-VasopressinMedium
[D-Cys6]-VasopressinMedium
[D-Arg8]-VasopressinMedium

[Leu7]-Vasopressin


……………………

Teriparatide [Des-Ser1]-PTH Teriparatide High
(Asp10)-PTH(1-34) Teriparatide   High
[D-Met18]TeriparatideMedium
[D-Asn33]-TeriparatideMedium
Glu6-PTH(1-34) Teriparatide Medium
PTH(1-31) Teriparatide  Medium
[Endo-Ser1]-PTH Teriparatide Medium
S-34-F[Met(0)18] Teriparatide Medium
……………………