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DMAP (4-Dimethylaminopyridine CAS:1122-58-3) is a new type of highly efficient catalyst widely used in chemical synthesis in recent years. The resonance between the electron donating dimethylamino group and the parent ring (pyridine ring) can strongly activate the nitrogen atom on the ring to carry out nucleophilic substitution. DMAP can significantly catalyze the acylation (phosphorylation, sulfonylation, carbonylation) of alcohols and amines with high resistance and low reactivity. Its activity is about 104-6 times that of pyridine . In organic synthesis, drug synthesis, pesticides, pharmaceuticals, dyes, spices, polymer chemistry, analytical chemistry, acylation, alkylation, etherification, esterification and transesterification and other types of reactions, it has a high catalytic capacity, and has an extremely obvious effect on improving the yield.
In addition, DMAP can be used as phase transfer catalyst for interfacial reaction. Its advantages are: small amount of catalyst, usually only reaction 01-5% of the molar number of the substrate, the acid produced by the reaction can be neutralized by organic or inorganic bases; the reaction conditions are mild, and the reaction can be carried out at room temperature, saving energy; the solvent selection range is wide, and can be carried out in polar and non-polar organic solvents; the reaction time is short, and the reaction can be completed by pyridine for a long time, while DMAP for a few minutes, thus greatly improving the labor productivity DMAP is one of the most commonly used catalysts in organic synthesis, which can improve the yield and product quality, simplify the process, reduce the side reaction, odor and three wastes. Because of its excellent catalytic performance, DMAP is called "super catalyst", which has become one of the most commonly used catalysts for organic synthesis workers.
Product Data Sheet
Appearance: light yellow or white crystal
Content: ≥ 99%
Water content: ≤ 0.5%
Water solubility: 7.6 g in 100 g water at 25 ℃
Boiling point: 162 ℃ (50mmhg)
Freezing point: 111.6 ℃
Flash point: 230 ℃
Registration number: 1122-58-3
Toxicity: LD50 = 230mg / kg
Solubility: soluble in water, ethanol, acetone, benzene, toluene, xylene, dichloroethane, chloroform, acetic acid, acetic anhydride, ethyl acetate, hexane, tetrahydrofuran, triethylamine, pyridine, DMF and other solvents.
Purpose: Super nucleophilic acylation catalyst
Caution: This product is toxic when taken orally or in contact with skin, and irritating to eyes, respiratory system and skin. When using it in large quantities, wear appropriate protective clothing, gloves and protective mask. In case of contact with eyes, wash it with plenty of water immediately and ask a doctor for diagnosis and treatment. In case of accident or discomfort, ask a doctor for diagnosis and treatment
Shipping & Storage
Packaging and storage: 1 kg / bag, 20 kg / box (barrel) cool, dry, sealed storage.
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