Peptide Knowledge Center

Wound repair application of bioactive peptides

Bioactive peptides refer to peptide compounds that are beneficial to the life activities of living organisms or have physiological effects, and multifunctional peptides mainly refer to some growth factors with specific functions. This article introduces the application of bioactive peptides in medical cosmetology, mainly in the application status and prospects of wound repair, anti-aging and anti-wrinkle, anti-sensitivity and acne-removing, moisturizing and whitening.

Biologically active peptide (Biologically active peptide or Bio.peptides), referred to as A. P active peptide, also known as functional peptide. Bioactive peptides refer to peptide compounds that are beneficial to the life activities of living organisms or have physiological effects. They are different peptides ranging from dipeptides to complex linear and cyclic structures composed of 20 natural amino acids in proteins in different compositions and arrangements. The general term for is also a multifunctional compound derived from protein. At present, the most widely used in cosmetics are cytokines such as epidermal growth factor (EGF), fibroblast growth factor (FGF), etc.; there are also some enzymes such as SOD, glutathione peroxidase, etc.

1. Wound repair applications

Cytokines can promote and accelerate cell growth, proliferation, synthesis of protein or polypeptide substances, and play an important role in skin wound repair. At present, the cytokines used in dermatology and cosmetology mainly include epidermal growth factor (EGF), which has a strong growth-promoting effect on epithelial cells, and fibroblast growth factor (FGF), which has a growth-promoting effect on fibroblasts and vascular endothelial cells. , insulin growth factor (IGF), platelet-derived factor (PDCF) and selective cell activator transforming growth factor p (TGF-B). . Fibroblast growth factor (FGF), transforming growth factor beta (TGF-B), epithelial growth factor (EGF) and platelet-derived growth factor (PDCF) can all induce angiogenesis in vivo, and they can directly interact with epithelial cell membrane surface specificity. The receptor binds to stimulate vascular epithelial migration and mitosis, and it can also indirectly promote endothelial cell replication and chemotactic migration through the secretion of active substances mediated by macrophages, and induce vascular proliferation. After stable structural repair or special protection treatment, cell growth factor is added to cosmetics at a certain effective concentration, which can effectively interact with skin cells, promote epithelial cell nutrition metabolism, protect skin and prevent skin from being caused by various reasons. damage. For example, epidermal growth factor (EGF) is a polypeptide substance composed of 53 amino acids with a molecular weight of 6000 Daltons. As a powerful cell division promoting factor, it can stimulate the division and proliferation of various types of tissue cells in the body and promote skin New cells are produced while repairing damaged skin rapidly. Huang Jizong and others discussed the application of various cytokine preparations to observe the efficacy of skin smoothness, comfort, whitening, and treatment of skin lesions. No side effects.

From Omizzur Biotech (