Chiral amino alcohols are important chiral compounds with optical activity. Because the N and O atoms in amino alcohol molecules with good coordination ability can form complexes with many elements, they are important chiral sources for the synthesis of chiral catalysts or ligands and some chiral compounds. Therefore, they are widely used in fine chemical industry, materials, medicine, biology and other organic synthesis and drugs, such as threoniol, propylamine alcohol, acetaminophen Phenylalanine alcohol has been used in peptide drugs and quinolone chiral drugs. Chiral amino alcohols have high stereoselectivity and catalytic efficiency, and the most successful one is the asymmetric alkylation of aldehydes

In a series of reactions, such as aromatization, aromatization and asymmetric Michael addition. Therefore, the study on the synthesis of chiral amino alcohol has a strong practical value.

There are several raw materials for the synthesis of chiral amino alcohols

1.Sugar is used as chiral source

2.keto as chiral source

3. Amine as chiral source

4. Amino acid as chiral source

Because amino acids exist widely in nature, it is the most common method to synthesize chiral amino alcohols from cheap and easily available amino acids.

The common raw materials can be phenylglycine, L-leucine, L-serine, L-valine and L-phenylalanine

5. Using cyclic amino alcohol as chiral source

Chiral amino alcohols have a wide range of applications, so the synthesis of chiral amino alcohols is still one of the important tasks for scholars in the future. It is of far-reaching significance to find new chiral catalysts or ligands and some chiral compounds.