Peptide Knowledge Center

Application of peptides in cosmetics (2)

Progeline, Trifuoroacetyl Tripeptide-2

Sequences: TFA-Val-Tyr-Val-OH

Application of peptides in cosmetics (2)

Trifuoroacetyl Tripeptide-2 is a tripeptide derived from an endogenous peptide (Elafin) in living organisms. It has the effect of protecting and promoting the production of skin structural proteins, while also playing a role in the basic metabolic function of skin cells. Therefore, it is called a new type of aging inhibitor.

Fluorinated peptides have significant anti-wrinkle and anti-aging effects. When used with 1000ppm stock solution or added to cream, they are non irritating, non allergenic, and can be used for a long time.


Acyltetrapeptide -9 can significantly improve the elasticity and structure of skin, which is a kind of polypeptide with anti-aging effect. An anti-aging peptide synthesized by the team of BASF in Germany also confirmed the anti-aging effect of acyl tetrapeptide in vivo experiments.

Whitening and freckle removing cosmetic peptides:

This type of peptide causes skin whitening by inhibiting melanin production, blocking melanin transmission, and inhibiting enzymes related to melanin production.


In the experiment, it was confirmed that Tetrapeptide-30 is an active raw material that can homogenize skin tone, and its active effect can be achieved at a concentration of 1600mg/kg in aqueous solution.

Nonapeptide-1 is a biomimetic peptide that acts as an antagonist to melanocyte stimulating hormones, preventing the production of melanin.

Hexapeptide-2 brightens skin tone quickly and effectively, known as brightening peptide. It brightens skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation, suitable for various skin tones.

Breast enhancement cosmetic peptides:

Acetylhexapeptide-38 regulates the rate of chest fat production, and ADIFYLINETM, developed by the Spanish company Lipotec SA team, is a peptide raw material. Increase the volume of local fat, containing acetylhexapeptide-38.

Weight loss and slimming:

Acetylhexapeptide-39 reduces the accumulation of subcutaneous fat and has the effect of weight loss and body beautification.

Removing eye bags:

Acetyltetrapeptide-5 and dipeptide-2 are effective angiotensin inhibitors that improve eye blood circulation.

Leather repair:

Palmitoyl hexapeptide-6 is a kind of peptide developed based on the template of genetic immune peptide, which can effectively stimulate the generation of fibroblasts, collagen synthesis and cell migration.

Precautions for using cosmetic peptides:

Cosmetic peptide raw materials have obvious effects in beauty and skincare products, but due to their high biological activity, some issues need to be noted in their application:

1. Peptide raw materials are mostly susceptible to environmental impact and inactivation. It is necessary to choose appropriate dosage forms and protective agents based on product characteristics to maintain their biological activity.

2. Choose appropriate application timing and methods based on different populations, skin conditions, and peptide characteristics, such as topical use, injection, oral administration, etc., to maximize biological activity.

3. All types of cells require the presence of multiple active peptides in order to maintain their appropriate proliferative state. A single active peptide has limited effects on cells and requires multiple peptides to work together to achieve the best effect.

4. Due to the dose-effect relationship of active peptides, as long as they can exert their beauty and skincare or wound repair effects, there is no need to pursue high concentrations in skincare products.


Article from Omizzur - custom peptide synthesis company in China