Classification of Amino Acids

The 20 common amino acids can be divided into several categories according to their side chains: aliphatic amino acids (Ala, Gly, Val, Leu, Ile,), aromatic amino acids (Phe, Tyr, Trp, His), amide or carboxyl side chain amino acids ( Asp, Glu, Asn, Gln), basic side chain amino acids (Lys, Arg), sulfur-containing amino acids (Cys, Met), alcohol-containing amino acids (Ser, Thr), imino amino acids (Pro)

Protected Amino Acids

The protection of amino acids in the chemical synthesis of polypeptides is very critical, which directly determines the key to the success of the synthesis. Because many of the common 20 amino acids have active side chains and need to be protected, it is generally required that these protecting groups are stable during the synthesis process, without side reactions, and can be completely and quantitatively removed after the synthesis.

Protected amino acids are the most basic raw materials for solid-phase peptide synthesis . Amino acids all contain alpha amino and carboxyl groups, and some of the 20 amino acids also contain side-chain active groups, such as hydroxyl, amino, guanidino and heterocyclic groups. These active groups need to be protected during the peptide reaction, and the protective groups are removed after the target peptide is synthesized.The most frequently used protected amino acid raw material is the Fmoc protected amino acids. 

Amino Acids that Need To Be Protected

Include: Cys, Asp, Glu, His, Lys, Asn, Gln, Arg, Ser, Thr, Trp, Tyr. Groups that need to be protected: hydroxyl, carboxyl, mercapto, amino, amido, guanidine, indole, imidazole, etc. Wherein Trp can also be unprotected, because indole is relatively stable in nature. Of course, under special circumstances, some amino acids may not be protected, such as Asn, Gln, Thr, Tyr.

Removal of Amino Acid Protecting Groups

There are many protecting groups for amino acid side chains. The same side chain has many different protecting groups, which can be selectively removed under different conditions. This is of great significance in the modification of cyclic peptides and polypeptides. Moreover, the side chain protecting group is closely related to the selected synthesis method. The liquid phase and the solid phase are different, and the BOC and FMOC strategies in the solid phase are also different. In a sense, peptide chemistry is the flexible use and matching of amino acid protecting groups

Omizzur Fmoc Amino Acids

Omizzur Biotech supply 1000+ Fmoc protected amino acids in peptide synthesis, Boc/Cbz, N-methyl amino acids, amino acid derivatives,unnatural amino acids,and high-purity peptide coupling, group protecting reagents, etc. All are available from stock , price with market advantage. Our products include but are not limited to the following varieties,if any needs, please contact the customer service center , our customer service staff will quickly feedback within 2 hours.

Omizzur is currently recruiting local high-quality partners,  has rich incentive policies for manufacturers or local dealers. Contact us to discuss cooperation matters now .