RGD peptides are a class of short peptides containing arginine-glycine-aspartic acid (Arg-Gly-Asp), which can be used as recognition sites for the interaction between integrins specifically expressed by tumor cells or new blood vessels and their ligands. Tumor-mediated targeted therapy has now demonstrated that cyclized peptides have more stable structures and stronger affinity. The cyclic RGD polypeptide containing two disulfide bonds has the strongest inhibitory effect on tumor neovascular endothelial cells, which is 20 times that of the cyclic RGD polypeptide containing a single disulfide bond and 200 times that of the linear RGD polypeptide. Biological coupling of substances is also one of the common methods of RGD peptide modification.

RGD peptide-modified tumor-targeted liposome drug delivery system Liposome is a vesicle-like structure formed by natural or synthetic lipids similar to biological membrane bilayers, which can encapsulate lipid-soluble Drugs can also encapsulate water-soluble drugs, so they are often used in the study of drug carriers. Especially surface modification by hydrophilic materials such as polyethylene glycol can prolong the circulation time of liposomes in vivo due to the steric hindrance, which can accumulate in tumor tissues and significantly improve the therapeutic index of the encapsulated drugs. . At the same time, the head-end of the polyethylene glycol derivative is further modified with RGD peptide, a new type of nano-long circulating liposome with active tumor vascular targeting can be obtained, thereby promoting the application of liposomes in tumor-targeted therapy applications in

RGD peptide-modified tumor-targeting polymer swelling-beam drug delivery system Micelle is a self-assembled nano-colloidal particle with a hydrophobic core and a hydrophilic shell, which is mainly used to deliver poorly water-soluble drugs. In particular, micelles formed by amphiphilic polymers have many advantages as drug carriers, have high stability, and can be widely used in the delivery of various types of poorly water-soluble drugs. The RGD peptide is attached to the end group of the polymer, and the RGD peptide competes with the integrin receptor on the tumor angiogenesis to transport the drug to the tumor site.

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