Peptide synthesis is a process of artificially synthesizing peptides through chemical methods outside the body. Protected amino acids is an important step in this process. This article is about 1200 words and will name over all commonly used Fmoc amino acids List and top 5 manufacturers for your reference and comparison.

Understand What is Protected Amino acid

Amino acids are the basic units that make up proteins, and they are linked together through peptide bonds to form polypeptide chains. Each amino acid molecule has an amino group (NH2), a carboxyl group (COOH), and a side chain (R).

In the process of peptide synthesis, we need to control the direction of the reaction so that amino acids can be connected in the order we set. This requires us to protect the amino and carboxyl groups of amino acids to prevent them from reacting when they are not needed.

There are many ways to protect amino acids, and the most common one is to use protective groups. A protective group is a chemical substance that can temporarily bind to an amino or carboxyl group, preventing these groups from participating in the reaction. When needed, we can remove the protective groups through chemical methods to reactivate the amino or carboxyl groups. Common protective groups include Fmoc group, boc group, Cbz group, etc.

9-Fluoromethoxycarbonyl (Fmoc group):

This is one of the most commonly used amino acid protecting groups, which can effectively protect amino acids from damage by acids, bases, and oxidants. Fmoc groups can be removed through hydrogenolysis reaction to generate free amino acids

20 Commonly used Fmoc Amino acids List for Peptide Synthesis

Fmoc Protected Unnatural Amino acids

There are far more than 20 types of amino acids, so scientists are trying to add new types of amino acids to proteins to give them new structures, properties, and functions, expanding the boundaries of macromolecular drug design.

The strong site specificity, wide substrate range, minimal disturbance to protein structure, and flexible use of non natural amino acid systems make them important applications in multiple disciplines such as structural biology, chemical biology, cell biology, and synthetic biology.

Fmoc protected unnatural amino acids refers to compounds that protect specific functional groups of non natural amino acids through Fmoc (fluorenylmethoxycarbonyl) groups. It has important value in peptide synthesis and protein engineering research and development, and is widely used in fields such as drug, food, and cosmetics research and development.

Fmoc Unnatural Amino acids List

Common Reagents for Ppeptide Synthesis & Production

This section of reagents is commonly used in peptide synthesis, including peptide coupling agents, protectants, linkers, labeling reagents, etc. The list is as follows:

Advantages of Top 5 Fmoc Amino Acids Manufacturers Worldwide

1. BACHEM 

Bachem is a world leading peptide company headquartered in Switzerland with a 50 year history. Bachem's core business covers the research and manufacturing of peptides, APIs (active pharmaceutical ingredients), and oligonucleotides, committed to improving product quality through advanced synthesis methods and technological means. 

Bachem is an important participant in the global pharmaceutical industry. Bachem has a total of over 1500 employees worldwide.

2. CEM Corporation

CEM was founded in 1978 by our current CEO, Dr. Michael J. Collins. For over 40 years CEM have designed and developed laboratory instrumentation and scientific methods that are used by major companies, prestigious research institutes, and universities around the world.

CEM is a private company with global headquarters outside Charlotte, North Carolina, along with offices in England, Germany, Japan, France, Italy, Singapore, and Ireland.

3. MilliporeSigma

MilliporeSigma is a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

MilliporeSigmais also a trusted biotech company, whose business covers almost all the synthesis of biomolecules such as peptides, proteins, cells, mRNA, and related detection services.

4. Omizzur

Omizzur is a company dedicated to the research and synthesis of peptides and fmoc amino acids. At present, there are over 600 types of amino acid derivatives available for spot supply.

All products have passed two quality inspections, and Omizzur has helped global R&D personnel reduce R&D costs and shorten delivery times: this is a young biotech company that focuses on efficiency and quality. 

Send an email to obtain their peptides and fmoc amino acids list & quotation: [email protected]

5. Senn Chemicals 

Senn Chemicals has been providing custom manufacturing services to pharmaceutical, biotechnology, diagnostic and cosmetic companies worldwide since 1963. Senn Chemicals' focus is on the manufacturing of peptides, peptide fragments, amino acid derivatives and small molecules. Senn Chemicals is also a trustworthy biotech company.