Peptide Knowledge Center
The future development direction of peptide drugs
With the maturity of peptide synthesis technology, biochemical and molecular biology technology, the research of peptide drugs has made epoch-making progress, and has become one of the important directions of research and development of pharmaceutical companies in various countries. Among the new drugs reviewed by the drug authorities in various countries, about 1/3 are peptide or protein drugs. In the future, the development of peptide drugs will focus on peptide immunity, expansion of peptide functions, and the research field of new peptide preparations.
1. Multifunctional peptide drugs
Multifunctional polypeptides can be polypeptides for various indications, or multiple polypeptides can be coupled to perform multiple functions. For example, antibiotic peptides also have other biological functions, such as increasing the body's immunity and wound repair. Albiglutide, liraglutide, etc. have been marketed as multifunctional peptide drugs.
2. Cell penetrating peptide
Traditional peptide drugs are difficult to cross cell membranes due to their physical and chemical properties. The cell-penetrating peptide is a special kind of peptide, which can directly enter the cell through the cell membrane. For example, TAT is the first cell-penetrating peptide to be discovered. Its method of entering cells is efficient and has no toxic side effects on cells. Cell penetrating peptides can mediate small molecules, nucleic acids, polypeptides, and proteins into cells and increase their absorption.
3. Coupling of peptides with other drugs
Polypeptides can be conjugated with small molecules, nucleotides, antibodies and other molecules, and the efficacy, safety, and targeting of the conjugate have been further improved. In the field of tumor therapy, more than 20 peptide-conjugated molecules have entered clinical trials.
4. Peptide vaccine
Traditional vaccines are divided into attenuated vaccines and inactivated vaccines. Polypeptide vaccines have the advantages of low price, high safety, and strong specificity. In addition, the peptide vaccine is artificially synthesized, and there is no phenomenon of virulence recovery or incomplete inactivation, and it is not easy to cause allergic reactions.
5. Antibacterial peptides
The problem of increased bacterial resistance is becoming more and more serious. The development of traditional antibacterial drugs is difficult. The clinical demand for new antibacterial drugs is particularly urgent. Unlike traditional antibacterial drugs, antibacterial peptides act on the cell membrane of bacteria, resulting in increased permeability, thereby killing the bacteria.
6. Antiviral peptides
Antiviral peptide drugs mainly act on virus adsorption receptors and virus replication stages, and peptides that bind to cell surface receptors can be screened from peptide libraries. These selected peptides have potential antiviral effects. The human immunodeficiency virus cell HIV is easy to mutate and has strong drug resistance. The peptide library is used to screen out the peptides against the envelope glycoprotein, which has a good anti-HIV effect. Some peptides have entered the clinical stage.
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