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Endometriosis is an estrogen dependent disease, which mostly occurs in women of childbearing age. The menstrual cycle of patients is short. Ectopic endometrial implants will lead to inflammation, scar and adhesion, and produce symptoms such as chronic pelvic pain, fatigue, dysmenorrhea, difficult sexual intercourse, periodic bleeding, difficult urination or defecation. In severe cases, it will lead to infertility. Surgery is the first choice for clinical treatment of endometriosis, but the recurrence rate is high. Therefore, in order to improve the treatment effect and reduce the recurrence rate, drug treatment is often given after operation. The initial treatment drugs include non steroidal anti-inflammatory drugs, compound oral contraceptives, etc., and then androgens, progesterone, gonadotropin releasing hormone analogue (GnRHa) and other main stream treatment drugs are gradually developed.
Leuproline is a highly active analogue of luteinizing hormone releasing hormone (GnRH) produced in the hypothalamus. It is a synthetic water-soluble nine peptide with two ends closed. Leuproline mainly regulates endocrine to treat prostate cancer, breast cancer, endometriosis and other sex hormone related diseases. Leuproline was ineffective after oral administration, and was well absorbed by subcutaneous or intramuscular injection. At present, its sustained-release preparations are mostly used in clinic.
Application of leuprorelin
Adjuvant therapy for breast cancer
Adenomyosis of uterus
Central precocious puberty
Assisted ovulation and in vitro fertilization
Product Data Sheet
Leuprorelin / leuprolide
|CAS||53714-56-0 (net), 74381-53-6 (acetate)|
|Type||Gonadotropin releasing hormone analogue|
|Source||custom peptide synthesis|
|Storage||-20 ± 5°C|
Shipping & Storage
It is valid for at least one year if stored at -20 ℃ or lower. Since each freezing and thawing of polypeptide will cause partial inactivation, after the storage solution with corresponding concentration is prepared for the first time (please prepare the storage solution according to the information in the column of reconstitution in the product introduction), it must be frozen at -20 ℃ or lower after sub packaging to avoid repeated freezing and thawing.
Shipping: By air or FedEx Express, delivery time: 5-10 days
Matters Needing Attention:
This product is freeze-dried powder. Since a small amount of polypeptide is deposited in the tube during the freeze-drying process, forming a very thin or invisible polypeptide layer, before opening the tube cover, we recommend centrifuging about 8000-12000g in a centrifuge for 10-30 seconds to make the polypeptide attached to the tube cover or tube wall gather at the bottom of the tube.
This product is only used for scientific research by professionals, and shall not be used for clinical diagnosis or treatment, food or drugs, or stored in ordinary houses.
For your safety and health, please wear lab clothes and disposable gloves.
1. For all batches of products, we will keep samples after one year of validity. When customers raise objections, we can make a quick response.
2. For the products purchased by customers, an original of our inspection report will be attached with the goods, including batch number, date, etc.
3. If you have any problems in use, please feel free to contact us and we will help you solve them as soon as possible.
1. After you confirm the purchase, please inform our sales staff of your detailed requirements, including product name, quantity, packaging requirements, etc., as well as your receiving address, company name and contact information; Then our sales staff will make an order for you.
2. Omizzur is a professional peptide manufacturer, there will be a huge discounts for bulk purchase. Distributors are welcomed.
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